'The Streets of San Francisco' revolves around homicide investigators Lt. Mike Stone and Assistant Inspector Steve Keller. Stone, a veteran cop with more than 20 years on the force, is faced with the task of mentoring young Keller, who has no experience in police work. Over time, Stone becomes a father figure to Keller, with the young investigator learning the art of detective work and eventually being promoted to inspector.
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Following the success of producing One Flew Over the Cuckoo's Nest (1975), Michael Douglas left the series at the beginning of the 1976-77 season. His character's absence was explained by having him take a teaching position.